Databases & Resources
List of Transcriptional regulator sites and transcription factors Databases at Nucleic Acid Research.
http://www.oxfordjournals.org/nar/database/subcat/1/4
TRANSFAC contains data on transcription factors, their experimentelly-proven binding sites, and regulated genes. Its broad compilation of binding sites allows the derivation of positional weight matrices.
http://www.gene-regulation.com/pub/databases.html
PathoDB® 2.0 Public 2005 is a database on pathologically relevant mutated forms of transcription factors and their binding sites.
http://www.gene-regulation.com/pub/databases.html
The Eukaryotic Promoter Database is an annotated non-redundant collection of eukaryotic POL II promoters, for which the transcription start site has been determined experimentally.
http://www.epd.isb-sib.ch/
DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information
http://dbtbs.hgc.jp/
ChlamyTFDB (1.0) is a public database arising from efforts to identify and catalogue all Chlamydomonas reinhardtii genes involved in transcriptional control.
http://plntfdb.bio.uni-potsdam.de/v3.0/
PlnTFDB (3.0) is a public database arising from efforts to identify and catalogue all Plant genes involved in transcriptional control.
http://rulai.cshl.edu/cgi-bin/TRED/tred.cgi?process=home
A Proteome Database of Transcription Factors
http://bioinf.uab.es/cgi-bin/trsdb/trsdb.pl
Over-represented Transcription Factor Binding Site Prediction Tool is a method base on TRANSFAC Matrix, it can detect over-represented motifs of known transcription factors from a set of related sequences. Particularly, promoters of a same gene family or from the same tissue can be submitted as a analysis subject. Promoters of putative co-regulated genes clustered with gene expression data should be also a good candidate to analysis.
http://www.bioinfo.tsinghua.edu.cn/~zhengjsh/OTFBS/
The high-quality transcription factor binding profile database
http://jaspar.cgb.ki.se/cgi-bin/jaspar_db.pl
Promoters
Compares two DNA sequences assuming colinear blocks, ideal for promoters.
http://www.ebi.ac.uk/Tools/Wise2/dbaform.html
Compares two DNA sequences allowing for inversions and translocations, ideal for promoters.
http://www.ebi.ac.uk/Tools/Wise2/promoterwise.html
An online tool using Neural Network Promoter Prediction version 2.2
http://www.fruitfly.org/seq_tools/promoter.html
Predicts Promoter regions based on scoring homologies with putative eukaryotic Pol II promoter sequences.
http://www-bimas.cit.nih.gov/molbio/proscan/
Promoter2.0 predicts transcription start sites of vertebrate PolII promoters in DNA sequences. It has been developed as an evolution of simulated transcription factors that interact with sequences in promoter regions. It builds on principles that are common to neural networks and genetic algorithms.
http://www.cbs.dtu.dk/services/Promoter/
Human, Mouse and Rat promoter extraction service
http://biowulf.bu.edu/zlab/PromoSer/
Prokaryotic promoter analysis
http://nostradamus.cs.rhul.ac.uk/%7Eleo/sak_demo/
Analysis of the promoter sequence of genes using TF-maps (maps of predicted transcription factors)
http://genome.imim.es/software/mmeta/index.html
Promoter region analysis by alignment of TF-maps (maps of predicted transcription factors)
http://genome.imim.es/software/meta/index.html
E. coli Promoter map
http://nostradamus.cs.rhul.ac.uk/%7Eleo/vigen/
PlantProm DB is an annotated, non-redundant collection of proximal promoter sequences for RNA polymerase II with experimentally determined transcription start site(s), TSS, from various plant species.
http://mendel.cs.rhul.ac.uk/mendel.php?topic=plantprom
PromEC is an updated compilation of E. coli mRNA promoter sequences.
http://margalit.huji.ac.il/promec/index.html
Neural Network Promoter Prediction
http://www.fruitfly.org/seq_tools/promoter.html
Transcription Factor Binding Sites
TESS is a web tool for predicting transcription factor binding sites in DNA sequences.
http://www.cbil.upenn.edu/cgi-bin/tess/tess
TFM (Transcription Factor Matrices) is a software suite for identifying and analyzing transcription factor binding sites in DNA sequences.
http://bioinfo.lifl.fr/TFM/
Regulatory VISTA combines transcription factor binding sites database search with a comparative sequence analysis. It can be used directly or through mVISTA, Genome VISTA, or VISTA Browser.
http://genome.lbl.gov/vista/rvista/submit.shtml
Searching Transcription Factor Binding Sites
http://www.cbrc.jp/research/db/TFSEARCH.html
Online tool to detect and visualize compositionally similar cis-element clusters in the context of conserved sequences. Within a high-scoring region, the relative arrangement of shared cis-elements within compositionally similar TF-binding site clusters is depicted in a Trafacgram.
http://trafac.cchmc.org/trafac/index.jsp
Phylogenetic footprinting is a method that identifies putative regulatory elements in DNA sequences. FootPrinter identifies regions of DNA that are unusually well conserved across a set of orthologous sequences.
http://genome.cs.mcgill.ca/cgi-bin/FootPrinter3.0/FootPrinterInput2.pl
TFM-Explorer (Transcription Factor Matrix Explorer) is a program for analysing regulatory regions of eukaryotic genomes.
http://bioinfo.lifl.fr/TFME/
This web application allows you to compare a set of position weight matrices (PWM) against the T-Reg database! T-Reg is a relational database on transcriptional regulation that contains a collection of PWMs.
http://treg.molgen.mpg.de/cgi-bin/pfm_meme_form.pl
SiteSeer: Visualisation and analysis of transcription factor binding sites in nucleotide sequences.
http://www.chick.manchester.ac.uk/SiteSeer/
EXPANDER (EXpression Analyzer and DisplayER) is a java-based tool for analysis of gene expression data. It is capable of (1) clustering (2) visualizing (3) biclustering and (4) performing downstream analysis of clusters and biclusters such as functional enrichment and promoter analysis. In particular, it can analyze groups of genes for enrichment of transcription factor binding sites in their promoters.
http://acgt.cs.tau.ac.il/expander/
Over-represented Transcription Factor Binding Site Prediction Tool.
http://www.bioinfo.tsinghua.edu.cn/~zhengjsh/OTFBS/
Mogul is a software tool that integrates multiple transcription factor binding site prediction algorithms into a common framework. Mogul provides access to a number of the most widely-used and popular predictions algorithms, organising them based on the predcitions that they make
http://xerad.systemsbiology.net/Mogul/
Method for identifying transcription factor binding sites in yeast
http://cg1.iis.sinica.edu.tw/~TFBSfinder/index.php
Transcription Terminators
TransTermHP finds rho-independent transcription terminators in bacterial genomes.
http://transterm.cbcb.umd.edu/
CpG Islands
CpG Islands searches for CpG islands in a DNA sequence using the method described by Gardiner-Garden and Frommer (1987).
http://www.geneinfinity.org/sms/sms_cpgislands.html
The CpG island searcher screens for CpG islands which meet the criteria selected below in submitted DNA sequences.
http://www.cpgislands.com/
CpG Island finder and plotting tool. An EMBOSS tool at the EBI that detects regions of genomic sequences rich in the CpG pattern.
http://www.ebi.ac.uk/Tools/emboss/cpgplot/
GrailEXP is a software package that predicts exons, genes, promoters, polyas, CpG islands, EST similarities, and repetitive elements within DNA sequence.
http://compbio.ornl.gov/Grail-1.3/
GC Content
Online server.
http://tubic.tju.edu.cn/GC-Profile/
Calculates fractional GC content of nucleic acid sequences
http://mobyle.pasteur.fr/cgi-bin/MobylePortal/portal.py?form=geecee