Nature Structural Biology

Most recent issue of Nature Structural Biology

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  • doi:10.1038/nsmb.3501

    Apolipoprotein A-I (apoA-I) is the scaffold protein that is essential for the assembly and function of HDL particles. A structural model for monomeric, lipid-free apoA-I, based on previous and new data, is now presented.' );return false" > A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state
  • doi:10.1038/nsmb.3503

    Asynchronous replication-timing patterns undergo programmed switching between maternal and paternal alleles in embryonic and adult stem cells.' );return false" > Programming asynchronous replication in stem cells
  • doi:10.1038/nsmb.3497

    Assembly of the small ribosomal subunit from an RNA strand and 33 proteins is an intricate and dynamic process. Two cryo-EM studies now provide insight into a complicated complex of at least 51 trans-factors that act on the preribosomal small subunit to sequentially fold it into a 3D molecular machine.' );return false" > Ribosome origami
  • doi:10.1038/nsmb.3502

    Cryo-EM analyses of human TRPML3 reveal this channel in three different states—closed, agonist-activated and low-pH-inhibited—and suggest mechanisms for regulation.' );return false" > Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states
  • doi:10.1038/nsmb.3500

    During transcription initiation, Ssl2, the dsDNA translocase of TFIIH, opens a 6-bp DNA bubble, suggesting a two-step model wherein Ssl2 triggers a 6-bp open complex that RNA polymerase II expands via NTP-dependent RNA transcription.' );return false" > TFIIH generates a six-base-pair open complex during RNAP II transcription initiation and start-site scanning
  • doi:10.1038/nsmb.3499

    Although deadenylation induces translational inhibition and mRNA decay, well-expressed transcripts are now shown to possess short, well-defined poly(A) tails, suggesting that pruned tails may be ideal for protective and translational functions.' );return false" > Short poly(A) tails are a conserved feature of highly expressed genes
  • doi:10.1038/nsmb.3498

    The cGAS-STING cytoplasmic-DNA-sensing pathway is activated by accumulation of extrachromosomal telomere repeats, and this proliferation-inhibition mechanism is defective in ALT cancer cells.' );return false" > Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway
  • doi:10.1038/nsmb.3496

    Disrupting the interaction between telomere protein TRF1 with meiosis-specific protein TERB1 impairs the pairing of X and Y chromosomes via their telomere-adjacent pseudoautosomal regions in pachytene, leading to spermatocyte apoptosis and male infertility in mice.' );return false" > Telomeric TERB1–TRF1 interaction is crucial for male meiosis
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