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Nature Medicine
Nature Medicine Advance Online Publication
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Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis
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Hypothalamic glucagon signaling inhibits hepatic glucose production
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Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection
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Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections
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Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator
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Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration
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Astrocyte-derived ATP modulates depressive-like behaviors
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Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
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Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
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A combination of fluorescent NFAT and H2B sensors uncovers dynamics of T cell activation in real time during CNS autoimmunity
Most recent issue of Nature Medicine
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Cancer therapy: A Notch further with SERCA
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Peli1 sets the CNS on fire
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Raising standards
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Establish good genomic practice to guide medicine forward
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Japan to offer fast-track approval path for stem cell therapies
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How antibiotics kill bacteria: new models needed?
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Delays in updates to ethics guidelines for research spark concern
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Allergy: Basophils meet monocytes
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Biomedical journal and publisher hope to bring preprints to life
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Meat-metabolizing bacteria in atherosclerosis
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After food and drug scandals, China's regulator gets a makeover
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The science police
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Dengue deluge highlights need for vaccine
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Viral infection: Therapeutic micromanagement
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Inhibitors of rogue enzyme near trials for brain and blood tumors
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Innate immunity: Immune cells muscle up
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Drug development for progeria yields insights into normal aging
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PPARγ signaling and metabolism: the good, the bad and the future
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With little research training, geriatricians pick clinic over the lab
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The shape of science
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Frailty research strengthens with biomarker and treatment leads
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A gut-heart connection in cardiometabolic regulation
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Old mice require new experimental tricks to study aging process
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Targeting RAF-MEK-ERK kinase-scaffold interactions in cancer
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Sequencing of superagers offers drug targets, but fewer than hoped
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Bad versus good cholesterol in the bone marrow
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New findings rejuvenate age-old drug development field
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Viral infection: Cloaked in a stolen envelope
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Living labs open door to retirees who want to join studies
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Cancer microenvironment: p53 acts in the hood
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Biomedical briefing
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New from NPG
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Straight talk with...Mandana Arabi
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Cytokines: Dual functions for interferons
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Rethinking the formula
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Fetomaternal immune cross-talk and its consequences for maternal and offspring's health
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How brown is brown fat? It depends where you look
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IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors
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Evidence for two types of brown adipose tissue in humans
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Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
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Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation
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Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis
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Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
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A colorectal cancer classification system that associates cellular phenotype and responses to therapy
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Regeneration and experimental orthotopic transplantation of a bioengineered kidney
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Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
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Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation
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GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
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PPARβ/δ governs Wnt signaling and bone turnover
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Targeting the endocannabinoid system in the treatment of fragile X syndrome
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