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  • doi:10.1038/nm.4448

    In the bone marrow, granulocyte-derived TNFα acts on endothelial cells to maintain the vasculature under steady-state conditions and to promote its regeneration after injury or transplantation.' );return false" > Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow
  • doi:10.1038/nm.4441

    Fry et al. report the first results from a human trial of a CD22-directed chimeric antigen receptor (CAR) T cell therapy providing evidence of efficacy in the treatment of pre–B cell acute lymphoblastic leukemia that is immunotherapy-naive or resistant to CD19-directed CAR T cells.' );return false" > CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy
  • doi:10.1038/nm.4437

    Genetic cell-lineage tracing studies in mice are crucial for delineating the contribution of stem and progenitor cells to different cell types, both in disease states and after regenerative therapy. He et al. have developed new genetic lineage-tracing systems that provide more definitive results than the commonly used Cre-based system and show that this new technology can resolve current controversies in the field, as demonstrated by lineage-tracing studies in the heart and liver.' );return false" > Enhancing the precision of genetic lineage tracing using dual recombinases
  • doi:10.1038/nm.4438

    Tumor organoids derived from the most common subtypes of primary liver cancer recapitulate the histologic and molecular features of the tissues of origin, even after long-term culture. These in vitro models, as well as those for colorectal cancer reported in Crespo et al. in a previous issue, are amenable for drug screening and allow the identification of therapeutic approaches with potential for cancer treatment.' );return false" > Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
  • doi:10.1038/nm.4429

    Calcium cycling induced by the SERCA2b–RyR2 pathway in beige fat cells allows for thermogenic activity independent of UCP1.' );return false" > UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis
  • doi:10.1038/nm.4444

    Pule and colleagues identify the TCR β-chain constant region as a new target for chimeric antigen receptor (CAR) T cells in treatment of T cell cancers while potentially preserving a healthy T cell repertoire. They demonstrate that anti-TCRB1 CAR T cells eliminate cancerous TCRB1+ T cells while sparing nearly one-third of normal TCRB2+ T cells.' );return false" > Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies
  • doi:10.1038/nm1117-1384a

    Corrigendum: Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation' );return false" > Corrigendum: Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation
  • doi:10.1038/nm1117-1384c

    Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice' );return false" > Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice
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