Nature Cell Biology

Most recent issue of Nature Cell Biology

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  • doi:10.1038/ncb3641

    Baarlink et al. identify a transient pool of nuclear F-actin, the dynamics of which are controlled by cofilin-1 that accumulates after mitosis and is important for chromatin reorganization in G1.' );return false" > A transient pool of nuclear F-actin at mitotic exit controls chromatin organization
  • doi:10.1038/ncb3638

    PARP inhibitors (PARPi) kill BRCA1/2-mutated cancers, which become resistant when DNA repair functions are restored. Now, MUS81 nuclease inhibition due to EZH2 downregulation is found to restore DNA replication fork protection but not repair, leading to PARPi-resistance in mutant BRCA2 cells and patients. This challenges the DNA repair dominance in synthetic lethality.' );return false" > PARPi focus the spotlight on replication fork protection in cancer
  • doi:10.1038/ncb3622

    Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome' );return false" > Erratum: Super-resolution microscopy reveals that disruption of ciliary transition-zone architecture causes Joubert syndrome
  • doi:10.1038/ncb3635

    Organoids are a powerful tool to study both physiological and disease processes. A completely synthetic matrix assembled from exchangeable modular parts has been developed and not only supports proliferation of human intestinal organoids derived from pluripotent embryonic stem cells, but also augments subsequent ad vivo implantation into injured murine colon.' );return false" > Implantable synthetic organoid matrices for intestinal regeneration
  • doi:10.1038/ncb3639

    A series of government reforms aim to enhance basic research efforts in China with a shift in focus from quantity to quality.' );return false" > Reforms spell optimism for biological research in China
  • doi:10.1038/ncb3637

    A variety of non-coding RNAs have been reported as endogenous sponges for cancer-modulating miRNAs. However, miRNA trapping by transcripts with protein-coding functions is less understood. The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16 on non-canonical miRNA response elements in melanoma, thereby promoting malignant growth.' );return false" > TYRP1 mRNA goes fishing for miRNAs in melanoma
  • doi:10.1038/ncb3627

    Shin et al. identify TBC1D23 as an adaptor that interacts both with golgins and endosomal WASH and is required for the delivery of endosome-derived vesicles to the trans-Golgi.' );return false" > TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi
  • doi:10.1038/ncb3631

    O’Farrell et al. show that class III PI3K regulates epithelial integrity through endosomal LKB1. Class III PI3K inactivation dysregulates LKB1 to alter cell polarity, and the PtdIns3P effector WDFY2 regulates LKB1.' );return false" > Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
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